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Article

The contribution of in vivo manipulation of gene expression to the understanding of the function of glypicans.

Glycoconjugate journal - 1 Jan 2000

Filmus Jorge

Abstract excerpt

The name glypican identifies a family of heparan sulfate proteoglycans that are linked to the cell surface by a glycosylphosphatidylinositol anchor. Members of this family have been identified in Drosophila, zebrafish, and mammals. The interest in the study of glypicans has increased in the last few years as a result of the discovery that the glypican-3 gene (GPC-3) is mutated in an overgrowth and dysmorphic...

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Identifiers

PMID: 12975611
DOI: 10.1023/A:1025312819804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The contribution of in vivo manipulation of gene expression to the understanding of the function of glypicans.PMID 12975611Read ↗

Fine-tuning of cell signaling by glypicans.Semantic proximity Read ↗

Alterations in mandibular morphology associated with glypican 1 and glypican 3 gene mutations.Semantic proximity Read ↗

Simpson Golabi Behmel syndrome: progress toward understanding the molecular basis for overgrowth, malformation, and cancer predisposition.Semantic proximity Read ↗

Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome.Semantic proximity Read ↗

Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.Semantic proximity Read ↗

Craniofacial skeletal defects of adult zebrafish Glypican 4 (knypek) mutants.Semantic proximity Read ↗

Mutation of the galectin-3 glycan-binding domain (Lgals3-R200S) enhances cortical bone expansion in male mice and trabecular bone mass in female mice.Semantic proximity Read ↗

What Have We Learned from Glycosyltransferase Knockouts in Mice?Semantic proximity Read ↗

Mutation of the Galectin-3 Glycan Binding Domain ( <i>Lgals3</i> -R200S) Enhances Cortical Bone Expansion in Male and Trabecular Bone Mass in Female MiceSemantic proximity Read ↗

Regulatory variation at glypican-3 underlies a major growth QTL in mice.Semantic proximity Read ↗

Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification.Semantic proximity Read ↗

Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome.Semantic proximity Read ↗

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