Article
Two distinct mechanisms of chromatin interaction by the Isw2 chromatin remodeling complex in vivo.
Molecular and cellular biology - 1 Nov 2005
Fazzio Thomas G, Gelbart Marnie E, Tsukiyama Toshio
Abstract excerpt
We have previously shown that Saccharomyces cerevisiae Isw2 complex slides nucleosomes to remodel chromatin in vivo. Our data suggested a model in which Isw2 complex binds the histone octamer and DNA separately to generate the force necessary for nucleosome movement. Here we find that the histone H4 "basic patch" is the only portion of any amino-terminal histone tail required for both target-specific association...
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