Article

The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability

2025-04-27

Abstract excerpt

<h4>Background</h4> ATP-dependent nucleosome remodeling complexes of the imitation switch (ISWI) family slide and space nucleosomes. The ISWI ATPase subunit forms obligate complexes with accessory subunits whose mechanistic roles remain poorly understood. In baker’s yeast, the Isw2 ATPase subunit associates with Itc1, the orthologue of human ACF1/BAZ1A. Prior data suggested that the genomic deletion of the 374 N-...

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Literature Corpus work: 565bed6b-8ad0-5bd1-9ed1-601d0220b968
DOI: 10.1101/2025.04.27.650761

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