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Article

Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant.

Genes & development - 15 Apr 2005

Gelbart Marnie E, Bachman Nurjana, Delrow Jeffrey, Boeke Jef D, Tsukiyama Toshio

Abstract excerpt

Isw2 ATP-dependent chromatin-remodeling activity is targeted to early meiotic and MATa-specific gene promoters in Saccharomyces cerevisiae. Unexpectedly, preferential cross-linking of wild-type Isw2p was not detected at these loci. Instead, the catalytically inactive Isw2p-K215R mutant is enriched at Isw2 targets, suggesting that Isw2p-K215R, but not wild-type Isw2p, is a sensitive chromatin immunoprecipitation...

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Identifiers

PMID: 15833917
DOI: 10.1101/gad.1298905
PMCID: PMC1080133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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