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Article

Evidence for close side-chain packing in an early protein folding intermediate previously assumed to be a molten globule.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2014

Rosen Laura E, Connell Katelyn B, Marqusee Susan

Abstract excerpt

The molten globule, a conformational ensemble with significant secondary structure but only loosely packed tertiary structure, has been suggested to be a ubiquitous intermediate in protein folding. However, it is difficult to assess the tertiary packing of transiently populated species to evaluate this hypothesis. Escherichia coli RNase H is known to populate an intermediate before the rate-limiting barrier to...

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Identifiers

PMID: 25258414
DOI: 10.1073/pnas.1410630111
PMCID: PMC4205613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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