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Article

Adenoviral E1a expression levels affect virus-selective replication in human cancer cells.

Cancer biology & therapy - 1 Nov 2005

Zheng Xinyu, Rao Xiao-Mei, Snodgrass Christina, Wang Min, Dong Yanbin, McMasters Kelly M, Zhou H Sam

Abstract excerpt

One of the promising strategies for targeting replication of oncolytic adenovirus in tumor cells is to regulate the expression of essential viral genes such as E1a by using tumor- or tissue-specific promoters that are preferentially active in cancer cells. However, this approach may lead to some degree of viral replication in normal cells other than in cancer cells if the viral gene also expresses in normal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16222119
DOI: 10.4161/cbt.4.11.2137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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