Article
Polymorphisms of the Nos3 gene and unexplained late intrauterine fetal death.
European journal of obstetrics, gynecology, and reproductive biology - 1 Oct 2005
Huber Ambros, Grimm Christoph, Jirecek Stefan, Heim Kurt, Zeillinger Robert, Husslein Peter, Hefler Lukas
Abstract excerpt
OBJECTIVE: Genetic polymorphisms associated with vascular diseases have been proposed to be involved in the pathogenesis of late unexplained intrauterine fetal death (IUFD). The Nos3 gene is known to regulate vascular tone via the endothelial nitric oxide synthase/nitric oxide pathway. STUDY DESIGN: In a multicenter case-control study, we evaluated two Nos3 polymorphisms (exon 7 Glu298Asp and a 27bp-repeat in...
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