Article
Association between TLR2/TLR4 gene polymorphisms and COPD phenotype in a Greek cohort.
Herz - 1 Dec 2017
Apostolou A, Kerenidi T, Michopoulos A, Gourgoulianis K I, Noutsias M, Germenis A E, Speletas M
Abstract excerpt
BACKGROUND: Considering that the innate immune system plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD), we hypothesized that functional single-nucleotide polymorphisms (SNPs) of innate immune genes affect the disease phenotype and prognosis. AIM: To elucidate the contribution of common functional TLR2 and TLR4 SNPs and genotypic deficiency of the mannose-binding lectin...
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