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Article

Association of TLR4-T399I polymorphism with chronic obstructive pulmonary disease in smokers.

Clinical & developmental immunology - 1 Jan 2009

Speletas Matthaios, Merentiti Vassiliki, Kostikas Konstantinos, Liadaki Kyriaki, Minas Markos, Gourgoulianis Konstantinos, Germenis Anastasios E

Abstract excerpt

Tobacco smoking has been considered the most important risk factor for chronic obstructive pulmonary disease (COPD) development. However, not all smokers develop COPD and other environmental and genetic susceptibility factors underlie disease pathogenesis. Recent studies have indicated that the impairment of TLR signaling might play a crucial role in the development of emphysema. For this purpose we investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20169003
DOI: 10.1155/2009/260286
PMCID: PMC2822240

Genes

TLR4
TLR2

Variants

Provenance

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