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Article

Substrate recognition by the human fatty-acid synthase.

The Journal of biological chemistry - 30 Dec 2005

Carlisle-Moore Loretha, Gordon Chris R, Machutta Carl A, Miller W Todd, Tonge Peter J

Abstract excerpt

The human fatty-acid synthase (HFAS) is a potential target for anti-tumor drug discovery. As a prelude to the design of compounds that target the enoyl reductase (ER) component of HFAS, the recognition of NADPH and exogenous substrates by the ER active site has been investigated. Previous studies demonstrate that modification of Lys-1699 by pyridoxal 5'-phosphate results in a specific decrease in ER activity. For...

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Identifiers

PMID: 16215233
DOI: 10.1074/jbc.M507082200
PMCID: PMC2442872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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