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Article

Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome.

Journal of enzyme inhibition and medicinal chemistry - 1 Oct 2007

Lloyd Matthew D, Boardman Kieren D E, Smith Andrew, van den Brink Daan M, Wanders Ronald J A, Threadgill Michael D

Abstract excerpt

Fatty aldehyde dehydrogenase (FALDH) is an NAD+-dependent oxidoreductase involved in the metabolism of fatty alcohols. Enzyme activity has been implicated in the pathology of diabetes and cancer. Mutations in the human gene inactivate the enzyme and cause accumulation of fatty alcohols in Sjögren-Larsson syndrome, a neurological disorder resulting in physical and mental handicaps. Microsomal FALDH was expressed...

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Identifiers

PMID: 18035827
DOI: 10.1080/14756360701425360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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