Article
Molecular characterization of human eye and heart fatty acid ethyl ester synthase/carboxylesterase by site-directed mutagenesis.
Biochemical and biophysical research communications - 26 Dec 2003
Bora Puran S, Guruge Bandula L, Bora Nalini S
Abstract excerpt
The FAEES/carboxylesterase enzyme nonoxidatively metabolizes alcohol into FAEEs, potentially toxic molecules linked with alcohol-induced end-organ damage. Our laboratory has isolated and characterized a FAEES/carboxylesterase cDNA from human eye and heart (G12). In an effort to further characterize the G12 enzyme, this laboratory has analyzed the FAEES activity, as well as performed mutagenic studies on a...
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