Article
Calcineurin regulates enteric muscle contraction through EXP-1, excitatory GABA-gated channel, in C. elegans.
Journal of molecular biology - 16 Sept 2005
Lee Jungsoo, Song Hyun-Ok, Jee Changhoon, Vanoaica Liviu, Ahnn Joohong
Abstract excerpt
The enteric muscle contraction (EMC) is the last step of the defecation behavior which occurs every 50 s in Caenorhabditis elegans. This EMC is regulated by intestinal and anal depressor muscles, which are innervated by GABA motor neurons. Our data show that calcineurin (tax-6) is expressed in intestinal muscle and anal depressor muscle, and the gain-of-function mutant of calcineurin, tax-6(jh107), shows defects...
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