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Article

Determination of the rate of muscarinic M1 receptor plasma membrane delivery using a regulated secretion/aggregation system.

Journal of pharmacological and toxicological methods - 1 Jan 2000

Sawyer Gregory W, Ehlert Frederick J, Hart Jon P

Abstract excerpt

INTRODUCTION: In this study, we used the regulated secretion/aggregation technology (RPD) to determine the rate of human muscarinic M1 (hM1) receptor plasma membrane delivery. METHODS: hM1 receptors were expressed in CHO cells as C-terminal fusion proteins to a conditional aggregation domain (CAD) consisting of four tandem mutant FKBP12 domains (F(m)). RESULTS: The CAD prevented the plasma membrane expression of...

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Source

Identifiers

PMID: 16213169
DOI: 10.1016/j.vascn.2005.08.006

Genes

CAD
NMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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