Article
Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes.
British journal of pharmacology - 1 Jul 2008
Liang Y, Woodward D F, Guzman V M, Li C, Scott D F, Wang J W, Wheeler L A, Garst M E, Landsverk K, Sachs G, Krauss A H-P, Cornell C, Martos J, Pettit S, Fliri H
Abstract excerpt
BACKGROUND AND PURPOSE: A prostamide analogue, bimatoprost, has been shown to be effective in reducing intraocular pressure, but its precise mechanism of action remains unclear. Hence, to elucidate the molecular mechanisms of this effect of bimatoprost, we focused on pharmacologically characterizing prostaglandin FP receptor (FP) and FP receptor variant (altFP) complexes. EXPERIMENTAL APPROACH: FP receptor mRNA...
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