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Article

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

The Journal of clinical investigation - 1 Nov 2005

Allan Sarah E, Passerini Laura, Bacchetta Rosa, Crellin Natasha, Dai Minyue, Orban Paul C, Ziegler Steven F, Roncarolo Maria Grazia, Levings Megan K

Abstract excerpt

Little is known about the molecules that control the development and function of CD4+ CD25+ Tregs. Recently, it was shown that the transcription factor FOXP3 is necessary and sufficient for the generation of CD4+ CD25+ Tregs in mice. We investigated the capacity of FOXP3 to drive the generation of suppressive CD4+ CD25+ Tregs in humans. Surprisingly, although ectopic expression of FOXP3 in human CD4+ T cells...

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Identifiers

PMID: 16211090
DOI: 10.1172/JCI24685
PMCID: PMC1242190

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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