Article
Matrix GLA protein gene polymorphisms: clinical correlates and cardiovascular mortality in chronic kidney disease patients.
American journal of nephrology - 1 Jan 2000
Brancaccio Diego, Biondi Maria Luisa, Gallieni Maurizio, Turri Olivia, Galassi Andrea, Cecchini Federica, Russo Domenico, Andreucci Vittorio, Cozzolino Mario
Abstract excerpt
BACKGROUND: Increased vascular calcification plays an important role in the pathogenesis of cardiovascular events in chronic kidney disease (CKD) patients. It is the result of an active ossification process counteracted by 'protective' proteins, such as matrix GLA protein (MGP). Polymorphisms of MGP have been identified. METHODS: The aim of this study was to define the distribution of two MGP polymorphisms (-7,...
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