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Article

Activation of the Src family kinase Hck without SH3-linker release.

The Journal of biological chemistry - 9 Dec 2005

Lerner Edwina C, Trible Ronald P, Schiavone Anthony P, Hochrein James M, Engen John R, Smithgall Thomas E

Abstract excerpt

Src family protein-tyrosine kinases are regulated by intramolecular binding of the SH2 domain to the C-terminal tail and association of the SH3 domain with the SH2 kinase-linker. The presence of two regulatory interactions raises the question of whether disruption of both is required for kinase activation. To address this question, we engineered a high affinity linker (HAL) mutant of the Src family member Hck in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16210316
DOI: 10.1074/jbc.M508782200

Genes

HAL

Variants

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Activation of the Src family kinase Hck without SH3-linker release.PMID 16210316Read ↗

SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.Semantic proximity Read ↗

Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk.Semantic proximity Read ↗

Genetically Encoded Förster Resonance Energy Transfer Sensors for the Conformation of the Src Family Kinase LckSemantic proximity Read ↗

Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6.Semantic proximity Read ↗

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.Semantic proximity Read ↗

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.Semantic proximity Read ↗

An intramolecular SH3-domain interaction regulates c-Abl activity.Semantic proximity Read ↗

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.Semantic proximity Read ↗

Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): comparison of the catalytic activities of CHK and CSK.Semantic proximity Read ↗

The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.Semantic proximity Read ↗

An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.Semantic proximity Read ↗

Modulation of human heat shock factor trimerization by the linker domain.Semantic proximity Read ↗

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