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Article

Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk.

Journal of molecular biology - 30 Jul 2004

Wong Lilly, Lieser Scot, Chie-Leon Barbara, Miyashita Osamu, Aubol Brandon, Shaffer Jennifer, Onuchic Josè N, Jennings Patricia A, Woods Virgil L, Adams Joseph A

Abstract excerpt

The SH2 domain is required for high catalytic activity in the COOH-terminal Src kinase (Csk). Previous solution studies suggest that a short peptide sequence, the SH2-kinase linker, provides a functional connection between the active site and the distal SH2 domain that could underlie this catalyt...

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Identifiers

PMID: 15312765
DOI: 10.1016/j.jmb.2004.05.060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15312765-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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