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Article

Potent block of inactivation-deficient Na+ channels by n-3 polyunsaturated fatty acids.

American journal of physiology. Cell physiology - 1 Feb 2006

Xiao Yong-Fu, Ma Li, Wang Sho-Ya, Josephson Mark E, Wang Ging Kuo, Morgan James P, Leaf Alexander

Abstract excerpt

A voltage-gated, small, persistent Na(+) current (I(Na)) has been shown in mammalian cardiomyocytes. Hypoxia potentiates the persistent I(Na) that may cause arrhythmias. In the present study, we investigated the effects of n-3 polyunsaturated fatty acids (PUFAs) on I(Na) in HEK-293t cells transfected with an inactivation-deficient mutant (L409C/A410W) of the alpha-subunit (hH1(alpha)) of human cardiac Na(+)...

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Identifiers

PMID: 16207794
DOI: 10.1152/ajpcell.00296.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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