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Article

TRF2 inhibition promotes anchorage-independent growth of telomerase-positive human fibroblasts.

Oncogene - 16 Feb 2006

Brunori M, Mathieu N, Ricoul M, Bauwens S, Koering C E, Roborel de Climens A, Belleville A, Wang Q, Puisieux I, Décimo D, Puisieux A, Sabatier L, Gilson E

Abstract excerpt

Although telomere instability is observed in human tumors and is associated with the development of cancers in mice, it has yet to be established that it can contribute to the malignant transformation of human cells. We show here that in checkpoint-compromised telomerase-positive human fibroblasts an episode of TRF2 inhibition promotes heritable changes that increase the ability to grow in soft agar, but not...

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Identifiers

PMID: 16205637
DOI: 10.1038/sj.onc.1209135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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