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Article

Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFbeta.

Oncogene - 16 Feb 2006

Hu B, Tack D C, Liu T, Wu Z, Ullenbruch M R, Phan S H

Abstract excerpt

Telomerase is induced in certain pathological conditions such as cancer and tissue injury and repair. This induction in fibroblasts from injured lung is repressed by transforming growth factor beta (TGFbeta) via yet unknown mechanisms. In this study, the role of Smad3 in the inhibition of telomerase reverse transcriptase (TERT) gene transcription by TGFbeta was investigated. The rat TERT (rTERT) gene promoter was...

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Source

Identifiers

PMID: 16205635
DOI: 10.1038/sj.onc.1209140

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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