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Article

Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression.

American journal of respiratory cell and molecular biology - 1 Sept 2003

Hu Biao, Wu Zhe, Phan Sem H

Abstract excerpt

Transforming growth factor-beta (TGF-beta)-induced alpha-smooth muscle actin (ASMA) expression is a key indicator of myofibroblast differentiation from fibroblasts. Recent studies suggest that a TGF-beta control element is important in the regulation of the ASMA gene promoter by TGF-beta. In this study, the role of Smad3, a key component of the Smad pathway that mediates TGF-beta signaling in regulation of ASMA...

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Identifiers

PMID: 12702545
DOI: 10.1165/rcmb.2003-0063OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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