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Functional Role of Calstabin2 in Age-related Cardiac Alterations

11 Dec 2014

Abstract excerpt

Calstabin2 is a component of the cardiac ryanodine receptor (RyR2) macromolecular complex, which modulates Ca(2+) release from the sarcoplasmic reticulum in cardiomyocytes. Previous reports implied that genetic deletion of Calstabin2 leads to phenotypes related to cardiac aging. However, the mechanistic role of Calstabin2 in the process of cardiac aging remains unclear. To assess whether Calstabin2 is involved in...

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PMID: 25502776
DOI: 10.1038/srep07425

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