Article
Mutations of presenilin genes in dilated cardiomyopathy and heart failure.
American journal of human genetics - 1 Dec 2006
Li Duanxiang, Parks Sharie B, Kushner Jessica D, Nauman Deirdre, Burgess Donna, Ludwigsen Susan, Partain Julie, Nixon Randal R, Allen Charles N, Irwin Robert P, Jakobs Petra M, Litt Michael, Hershberger Ray E
Abstract excerpt
Two common disorders of the elderly are heart failure and Alzheimer disease (AD). Heart failure usually results from dilated cardiomyopathy (DCM). DCM of unknown cause in families has recently been shown to result from genetic disease, highlighting newly discovered disease mechanisms. AD is the most frequent neurodegenerative disease of older Americans. Familial AD is caused most commonly by presenilin 1 (PSEN1)...
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