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Article

Calsenilin reverses presenilin-mediated enhancement of calcium signaling

18 Jul 2000

Abstract excerpt

Most cases of autosomal-dominant familial Alzheimer's disease are linked to mutations in the presenilin genes (PS1 and PS2). In addition to modulating beta-amyloid production, presenilin mutations also produce highly specific and selective alterations in intracellular calcium signaling. Although the molecular mechanisms underlying these changes are not known, one candidate molecular mediator is calsenilin, a...

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PMID: 10900016
DOI: 10.1073/pnas.97.15.8590

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