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Article

Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1.

Cancer research - 1 Oct 2005

Salhia Bodour, Rutten Frederieke, Nakada Mitsutoshi, Beaudry Christian, Berens Michael, Kwan Allison, Rutka James T

Abstract excerpt

Malignant astrocytomas are highly invasive neoplasms infiltrating diffusely into regions of normal brain. Whereas the molecular and cellular mechanisms governing astrocytoma invasion remain poorly understood, evidence in other cell systems has implicated a role for the Rho-GTPases in cell motility and invasion. Here, we examine how the inhibition or activation of Rho-kinase (ROCK) affects astrocytoma morphology,...

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PMID: 16204049
DOI: 10.1158/0008-5472.CAN-05-0160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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