Article
In vivo evolution of the gp90 gene and consistently low plasma viral load during transient immune suppression demonstrate the safety of an attenuated equine infectious anemia virus (EIAV) vaccine.
Archives of virology - 1 Jan 2009
Ma Jian, Jiang Chenggang, Lin Yuezhi, Wang Xuefeng, Zhao Liping, Xiang Wenhua, Shao Yiming, Shen Rongxian, Kong Xiangang, Zhou Jianhua
Abstract excerpt
To study the in vivo evolution of the attenuated Chinese equine infectious anemia virus (EIAV) vaccine, viral gp90 gene variation and virus replication in immunosuppressed hosts were investigated. The results showed that after vaccination, the gp90 gene followed an evolutionary trend of declining diversity. The trend coincided with the maturation of immunity to EIAV, and eventually, the gp90 gene became highly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.