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Epstein-Barr virus induces fragmentation of chromosomal DNA during lytic infection

1 Dec 1993

Abstract excerpt

Pulsed-field agarose gel electrophoresis showed that fragmentation of chromosomal DNA in Raji cells was induced by infection with the P3HR-1 strain of Epstein-Barr virus (EBV). S1 nuclease treatment of the agarose plugs containing cells suggested that the majority of DNA fragments did not contain single-strand gaps. Chromosomal DNA fragmentation was inhibited by cycloheximide, indicating that protein synthesis...

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PMID: 8230485
DOI: 10.1128/jvi.67.12.7654-7658.1993

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