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Article

Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism

5 Jan 2007

Abstract excerpt

Viral infections trigger innate immune responses, including the production of type I interferons (IFN-alpha and -beta) and other proinflammatory cytokines. Novel antiviral cytokines IFN-lambda1, IFN-lambda2, and IFN-lambda3 are classified as type III IFNs and have evolved independently of type I IFNs. Type III IFN genes are regulated at the level of transcription and induced by viral infection. Although the...

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PMID: 17204473
DOI: 10.1074/jbc.m608618200

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