Article
The FCGR2A--Arg131 variant is no major mortality factor in the elderly--evidence from a German centenarian study.
International journal of immunogenetics - 1 Aug 2006
Flesch B K, Nikolaus S, El Mokhtari N E, Schreiber S, Nebel A
Abstract excerpt
The functional single nucleotide polymorphism rs1801274 in the FCGR2A gene (His131Arg) influences the efficiency of hIgG2 binding, the main isotype produced in response to encapsulated bacteria like Streptococcus pneumoniae and Haemophilus influenzae. In contrast to the receptor with the His131 allele, FcgammaRIIa-Arg131 binds hIgG2 poorly and carriers of this variant have been shown to be much more susceptible...
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