Article
A structure-based approach to predict predisposition to amyloidosis.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2015
Ahmed Abdullah B, Znassi Nadia, Château Marie-Thérèse, Kajava Andrey V
Abstract excerpt
BACKGROUND: Neurodegenerative diseases and other amyloidoses are linked to the formation of amyloid fibrils. It has been shown that the ability to form these fibrils is coded by the amino acid sequence. Existing methods for the prediction of amyloidogenicity generate an unsatisfactory high number of false positives when tested against sequences of the disease-related proteins. METHODS: Recently, it has been shown...
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