Article
Uranyl acetate induces hprt mutations and uranium-DNA adducts in Chinese hamster ovary EM9 cells.
Mutagenesis - 1 Nov 2005
Stearns Diane M, Yazzie Monica, Bradley Andrew S, Coryell Virginia H, Shelley Jake T, Ashby Adam, Asplund Craig S, Lantz R Clark
Abstract excerpt
Questions about possible adverse health effects from exposures to uranium have arisen as a result of uranium mining, residual mine tailings and use of depleted uranium in the military. The purpose of the current study was to measure the toxicity of depleted uranium as uranyl acetate (UA) in mammalian cells. The activity of UA in the parental CHO AA8 line was compared with that in the XRCC1-deficient CHO EM9 line....
Topics
- Animals
- CHO Cells
- Cell Survival
- Comet Assay
- Cricetinae
- Cricetulus
- DNA Adducts
- DNA Damage
- DNA-Formamidopyrimidine Glycosylase
- Dose-Response Relationship, Drug
- Female