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Article

Biological aging and the etiology of aneuploidy

1 Jan 2005

Abstract excerpt

A prevalent hypothesis concerning the cause of the rise in aneuploid conceptions with maternal age is that the changes that accompany normal ovarian aging increase the rate of meiotic errors in the oocyte. Biological aging of the ovary is accompanied by a decline in both the total oocyte pool and the number of antral follicles maturing per cycle, as well as changes in the levels of circulating reproductive...

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PMID: 16192704
DOI: 10.1159/000086899

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