Maternal age effect: the enigma of Down syndrome and other trisomic conditions.

doi:10.1016/0165-1110(92)90033-6

Back to search

Article

Maternal age effect: the enigma of Down syndrome and other trisomic conditions.

Mutation research - 1 Dec 1992

Gaulden M E

Abstract excerpt

Aneuploidy is the most frequently observed chromosome abnormality in human liveborn, abortuses and oocytes. The only etiological factor that has been established is advanced maternal age for the occurrence of trisomies, particularly trisomy 21 which causes Down syndrome. The maternal age effect r...

Topics

Aneuploidy
Down Syndrome
Female
Fertilization
Gonadal Steroid Hormones
Humans
Male
Maternal Age
Mutation
Nondisjunction, Genetic
Oocytes
Trisomy

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.