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Article

Ovarian Aging: Mechanisms and Clinical Consequences

9 Jul 2009

Abstract excerpt

Menopause is the final step in the process referred to as ovarian ageing. The age related decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of menses. The parallel decay in oocyte quality contributes to the gradual decline in fertility and the final occurrence of natural sterility. Endocrine changes mainly relate to the decline in the negative feedback from ovarian...

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Identifiers

PMID: 19589949
DOI: 10.1210/er.2009-0006

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