Article
Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS.
Immunogenetics - 1 Oct 2005
Soriano Alex, Lozano Francisco, Oliva Harold, García Felipe, Nomdedéu Meritxell, De Lazzari Elisa, Rodríguez Carmen, Barrasa Alicia, Lorenzo José I, Del Romero Jorge, Plana Montserrat, Miró José M, Gatell José M, Vives Jordi, Gallart Teresa
Abstract excerpt
Interleukin (IL) 4 is a key T helper-2 cytokine that downregulates and upregulates CCR5 and CXCR4, respectively, the main coreceptors for HIV. Our objective is to investigate whether single-nucleotide polymorphisms (SNPs) in the IL-4 receptor alpha chain gene (IL4RA) affect HIV infection and its progression to AIDS. The I50V SNP in exon 5 and the haplotypes of six SNPs in exon 12 (E375A, C406R, S411L, S478P,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.