Article
Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease.
BMC medical genetics - 28 Sept 2005
Hoffjan Sabine, Stemmler Susanne, Parwez Qumar, Petrasch-Parwez Elisabeth, Arinir Umut, Rohde Gernot, Reinitz-Rademacher Karin, Schultze-Werninghaus Gerhard, Bufe Albrecht, Epplen Jörg T
Abstract excerpt
BACKGROUND: For allergic disorders, the increasing prevalence over the past decade has been attributed in part to the lack of microbial burden in developed countries ('hygiene hypothesis'). Variation in genes encoding toll-like receptors (TLRs) as the receptor system for the first innate immune r...
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