Article
Short polyglutamine tracts in the androgen receptor are protective against breast cancer in the general population.
Cancer research - 1 Aug 2001
Giguère Y, Dewailly E, Brisson J, Ayotte P, Laflamme N, Demers A, Forest V I, Dodin S, Robert J, Rousseau F
Abstract excerpt
We studied the association of breast cancer with the polymorphic polyglutamine repeat of the androgen receptor (AR) in 255 incident cases of breast cancer and 461 matched controls from the Quebec City metropolitan area. Women for whom the sum of both of the AR (CAG)n-repeats alleles is 39 or less (short-allele AR genotypes) have one-half the risk of breast cancer compared with women for whom the sum of AR...
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