Article
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.
Nature genetics - 1 Oct 2005
Reich David, Patterson Nick, De Jager Philip L, McDonald Gavin J, Waliszewska Alicja, Tandon Arti, Lincoln Robin R, DeLoa Cari, Fruhan Scott A, Cabre Philippe, Bera Odile, Semana Gilbert, Kelly M Ann, Francis David A, Ardlie Kristin, Khan Omar, Cree Bruce A C, Hauser Stephen L, Oksenberg Jorge R, Hafler David A
Abstract excerpt
Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle,...
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