Article
Spinocerebellar ataxia type 1, 2, and 3 and restless legs syndrome: striatal dopamine D2 receptor status investigated by [11C]raclopride positron emission tomography.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2006
Reimold Matthias, Globas Christoph, Gleichmann Marc, Schulze Michael, Gerloff Christian, Bares Roland, Machulla H-J, Bürk Katrin
Abstract excerpt
In spinocerebellar ataxias (SCAs), up to 30% of patients complain of restless legs syndrome (RLS). In primary RLS, a putative role of the dopaminergic system has been postulated. To assess dopaminergic function in SCA1, 2, and 3, dopamine D(2) receptor binding potential (BP) was assessed by [(11)C]raclopride positron emission tomography in 10 SCA patients, 4 of whom suffered from RLS as demonstrated by...
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