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Article

Induction of Replication in Human Corneal Endothelial Cells by E2F2 Transcription Factor cDNA Transfer

26 Sept 2005

Abstract excerpt

PURPOSE: Corneal endothelial cells in humans do not replicate to any meaningful extent. Diminishing density of the cell monolayer with age and in the disease states is a major cause of loss of corneal transparency. This study was conducted to test the hypothesis that overexpression of the transcription factor E2F2 results in replication in nonproliferating human corneal endothelial cells. METHODS: Whole human...

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Identifiers

PMID: 16186339
DOI: 10.1167/iovs.04-0551

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