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Article

HIV protease inhibitors block adipocyte differentiation independently of lamin A/C.

AIDS (London, England) - 14 Oct 2005

Kudlow Brian A, Jameson Samantha A, Kennedy Brian K

Abstract excerpt

OBJECTIVES: To determine the importance of lamin A/C for fat cell differentiation in vitro and for the anti-adipogenic activity of HIV protease inhibitors such as indinavir. METHODS: Lipodystrophy-associated and processing-defective mutants of lamin A were stably expressed at high levels in 3T3-L1 pre-adipocytes. Additionally, 3T3-L1 pre-adipocytes with stable reduction of lamin A/C or emerin were derived. The...

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Protease Inhibitors

Share to Indinavir

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Source

Identifiers

PMID: 16184025
DOI: 10.1097/01.aids.0000186827.91408.90

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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