Article
BRAF mutations in papillary carcinomas of the thyroid.
Oncogene - 25 Sept 2003
Fukushima Toshihiko, Suzuki Shinichi, Mashiko Miyuki, Ohtake Tohru, Endo Yoshiyuki, Takebayashi Yuji, Sekikawa Koji, Hagiwara Koichi, Takenoshita Seiichi
Abstract excerpt
BRAF is a serine/threonine kinase that receives a mitogenic signal from RAS and transmits it to the MAP kinase pathway. Recent studies have reported that mutations of the BRAF gene were detected with varying frequencies in several cancers, notably more than 60% in melanoma. We analysed mutations of BRAF and RAS genes in 100 cases of thyroid carcinoma to investigate genetic aberrations in the RAS/RAF/MEK/MAP...
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