Article
Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease.
Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2005
Bayona-Bafaluy Maria Pilar, Blits Bas, Battersby Brendan J, Shoubridge Eric A, Moraes Carlos T
Abstract excerpt
Frequently, mtDNA with pathogenic mutations coexist with wild-type genomes (mtDNA heteroplasmy). Mitochondrial dysfunction and disease ensue only when the proportion of mutated mtDNAs is high, thus a reduction in this proportion should provide an effective therapy for these disorders. We developed a system to decrease specific mtDNA haplotypes by expressing a mitochondrially targeted restriction endonuclease,...
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