Article
Immunotherapy of mammary adenocarcinoma metastases in C3H/HeN mice with chronic administration of cyclo-oxygenase inhibitors alone or in combination with IL-2.
Clinical & experimental metastasis - 1 Jul 1992
Khoo N K, Chan F P, Saarloos M N, Lala P K
Abstract excerpt
In this study the efficacy of treatment of two cyclo-oxygenase inhibitors, ibuprofen (Ibu) and indomethacin (Indo), are compared in the immunotherapy of metastasis designed to reverse prostaglandin E2 (PGE2)-mediated inactivation of interleukin-2 (IL-2)-dependent host killer cell lineages. These agents were tested either alone for the prevention of metastasis or in combination with IL-2 for the eradication of...
Topics
- Adenocarcinoma
- Animals
- Cell Division
- Cyclooxygenase Inhibitors
- Drug Therapy, Combination
- Female
- Ibuprofen
- Immunotherapy
- Indomethacin
- Interleukin-3
- Killer Cells, Natural