Article
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway.
Acta pharmacologica Sinica - 1 Dec 2021
Wu Ya-Xian, Wang Ying-Ying, Gao Zhi-Qi, Chen Dan, Liu Gang, Wan Bin-Bin, Jiang Feng-Juan, Wei Ming-Xia, Zuo Jing, Zhu Jun, Chen Yong-Quan, Qian Feng, Pang Qing-Feng
Abstract excerpt
Ethyl ferulate (EF) is abundant in Rhizoma Chuanxiong and grains (e.g., rice and maize) and possesses antioxidative, antiapoptotic, antirheumatic, and anti-inflammatory properties. However, its effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) is still unknown. In the present study, we found that EF significantly alleviated LPS-induced pathological damage and neutrophil infiltration and inhibited...
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