Activation-induced depletion of protein kinase C alpha provokes desensitization of monocytes/macrophages in sepsis.

Abstract excerpt

Sepsis accounts for the majority of fatal casualties in critically ill patients, because extensive research failed to significantly improve appropriate therapy strategies. Thus, understanding molecular mechanisms initiating the septic phenotype is important. Symptoms of septic disease are often associated with monocyte/macrophage desensitization. In this study, we provide evidence that a desensitized cellular...

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