Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer

24 Oct 2006

Abstract excerpt

Artemis gene mutations are responsible for the development of a severe combined immunodeficiency [radiation-sensitive (RS) SCID] characterized by a severe B and T cell deficiency and a normal natural killer cell population. To establish the feasibility of a gene therapy approach to the treatment of RS-SCID, we generated a series of lentiviral vectors expressing human Artemis from different promoters and used them...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to RNA Interference and Gene Delivery
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17062750
DOI: 10.1073/pnas.0608130103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transferPMID 17062750Read ↗

Stable and Functional Lymphoid Reconstitution in Artemis-deficient Mice Following Lentiviral Artemis Gene Transfer Into Hematopoietic Stem CellsSemantic proximity Read ↗

Cytotoxicity Associated with Artemis Overexpression After Lentiviral Vector-Mediated Gene TransferSemantic proximity Read ↗

Lentivirus Mediated Correction of Artemis-Deficient Severe Combined ImmunodeficiencySemantic proximity Read ↗

Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families.Semantic proximity Read ↗

Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow.Semantic proximity Read ↗

A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation.Semantic proximity Read ↗

Restoration of Human B-cell Differentiation Into NOD-SCID Mice Engrafted With Gene-corrected CD34+ Cells Isolated From Artemis or RAG1-deficient PatientsSemantic proximity Read ↗

Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency.Semantic proximity Read ↗

Clinical Applications of Gene Therapy for Primary ImmunodeficienciesSemantic proximity Read ↗

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis.Semantic proximity Read ↗

Gene therapy for severe combined immunodeficiency: are we there yet?Semantic proximity Read ↗

The V(D)J recombination/DNA repair factor artemis belongs to the metallo-beta-lactamase family and constitutes a critical developmental checkpoint of the lymphoid system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.