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Article

Heat stress promotes mitochondrial instability and oxidative responses in yeast deficient in thiazole biosynthesis.

Research in microbiology - 1 Apr 2006

Medina-Silva Renata, Barros Marcelo P, Galhardo Rodrigo S, Netto Luis E S, Colepicolo Pio, Menck Carlos F M

Abstract excerpt

The Thi4 protein from Saccharomyces cerevisiae plays a pivotal role in the biosynthesis of thiazole, a precursor of thiamine (vitamin B1). In addition, the thi4-disrupted strain has shown increased frequencies of mitochondrial mutants (petite colonies) upon treatment with DNA damaging agents. In this work, we show that the thi4 strain presents significant induction of petites and reduced oxygen consumption when...

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Identifiers

PMID: 16171982
DOI: 10.1016/j.resmic.2005.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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